Episode 486 - Bypassing the brains defences for treatment

The brain is incredibly important and needs to be protected by your body but this also makes it hard to treat. Brain tumours can be stubborn to root out because many treatments are blocked by the blood brain barrier. The blood brain barrier blocks many cancer treatments, but with the right disguise and nano coating cancer treatments can sneak past. Brain tumours can block the immune system from functioning, but sneaking through the right treatment can help the immune system fight back. Traumatic brain injury and subsequent inflammation can lead to significant damage, and normal anti-inflammatory methods are blocked by the blood brain barrier. If you can't sneak anti-inflammatories through the blood brain barrier, why not just boost their production locally? T Cells can fight back against inflammation after a traumatic brain injury if there's enough food for them to thrive on. 

1. Yshii, L., Pasciuto, E., Bielefeld, P. et al. Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nat Immunol, 2022 DOI: 10.1038/s41590-022-01208-z
2. Mahmoud S. Alghamri, Kaushik Banerjee, Anzar A. Mujeeb, Ava Mauser, Ayman Taher, Rohit Thalla, Brandon L. McClellan, Maria L. Varela, Svetlana M. Stamatovic, Gabriela Martinez-Revollar, Anuska V. Andjelkovic, Jason V. Gregory, Padma Kadiyala, Alexandra Calinescu, Jennifer A. Jiménez, April A. Apfelbaum, Elizabeth R. Lawlor, Stephen Carney, Andrea Comba, Syed Mohd Faisal, Marcus Barissi, Marta B. Edwards, Henry Appelman, Yilun Sun, Jingyao Gan, Rose Ackermann, Anna Schwendeman, Marianela Candolfi, Michael R. Olin, Joerg Lahann, Pedro R. Lowenstein, Maria G. Castro. Systemic Delivery of an Adjuvant CXCR4–CXCL12 Signaling Inhibitor Encapsulated in Synthetic Protein Nanoparticles for Glioma Immunotherapy. ACS Nano, 2022; DOI: 10.1021/acsnano.1c07492