Lagrange Point

Lagrange Point Episode 535 - Trees growing faster during droughts

As our climate changes extreme weather events become more common, but what does this mean for ecosystems? Ecosystems and plants that have adapted to on extreme climate, can thrive in another. An adaption that helps you survive in extreme cold can be very helpful when there is a drought. There is a balancing act between choosing when to grow and when to conserve energy. Plants carefully manage their resources in extreme drought and extreme cold. 

1. Joan Dudney, Andrew M. Latimer, Phillip van Mantgem, Harold Zald, Claire E. Willing, Jonathan C. B. Nesmith, Jennifer Cribbs, Elizabeth Milano. The energy–water limitation threshold explains divergent drought responses in tree growth, needle length, and stable isotope ratios. Global Change Biology, 2023; DOI: 10.1111/gcb.16740

Episode 534 - Finding a rocky asteroid belt around another star

Asteroid belts are harder to find than Sci-fi would have you believe. Spotting an asteroid belt is easier in the outer solar system, but closer in it gets a bit more blurry. Using the JWT we can use more than just visible light to find tricky interstellar objects. Asteroid belts are messy but they can tell us a lot about a solar system by what they leave in their wake. 

Reference:

1. András Gáspár, Schuyler Grace Wolff, George H. Rieke, Jarron M. Leisenring, Jane Morrison, Kate Y. L. Su, Kimberly Ward-Duong, Jonathan Aguilar, Marie Ygouf, Charles Beichman, Jorge Llop-Sayson, Geoffrey Bryden. Spatially resolved imaging of the inner Fomalhaut disk using JWST/MIRI. Nature Astronomy, 2023; DOI: 10.1038/s41550-023-01962-6

Episode 533 - Bacteria melting ice and changing the planet

How can tiny bacteria change the entire planet? Greenland is beautiful and covered in glaciers, but they are turning more and more dark and black. Black algae is tinting glaciers in Greenland darker, and causing changes in our climate. The more our climate changes, the easier it is for algae to thrive in glacier runoff and change the colours of the glaciers. Algae can survive in strange locations on earth, what can that teach us about microorganisms across the solar system? 

1. James A. Bradley, Christopher B. Trivedi, Matthias Winkel, Rey Mourot, Stefanie Lutz, Catherine Larose, Christoph Keuschnig, Eva Doting, Laura Halbach, Athanasios Zervas, Alexandre M. Anesio, Liane G. Benning. Active and dormant microorganisms on glacier surfaces. Geobiology, 2022; 21 (2): 244 DOI: 10.1111/gbi.12535

Episode 532 - Bacteria reviving themselves when the time is right

Bacteria are masters of survival, pausing and shielding themselves when times get tough. So how do they know when to wake up? The mechanisms bacteria use to survive harsh conditions are one of the reasons they're able to survive so well. The protective layers and pausing all activity inside the cell enable the bacteria, as a spore, to survive very long periods of time. After suspending themselves through a tough period of time,how do bacteria wake themselves up?

 

1. Yongqiang Gao, Jeremy D. Amon, Lior Artzi, Fernando H. Ramírez-Guadiana, Kelly P. Brock, Joshua C. Cofsky, Deborah S. Marks, Andrew C. Kruse, David Z. Rudner. Bacterial spore germination receptors are nutrient-gated ion channels. Science, 2023; 380 (6643): 387 DOI: 10.1126/science.adg9829

Lagrange Point Episode 531 - Measuring the expansion of the universe

Understanding the future of the universe requires peering into the past. How quickly the universe is expanding has been an active area of science since the 1920s, with several prizes and breakthroughs. Each time we get new or more accurate measurements it forces scientists to re-evaluate the assumptions and formulas. These breakthroughs then need to be confirmed with follow up studies. The measurement of Hubble's constant using supernova won a Nobel Prize in 2011, and new gravitational lensing measurements have provided extra confirmation to those numbers. Dark matter can influence a lot in our universe, but measuring it is difficult but using lensing techniques a more accurate measurement can be derived.

1. Mauricio Cruz Reyes, Richard I. Anderson. A 0.9% calibration of the Galactic Cepheid luminosity scale based on Gaia DR3 data of open clusters and Cepheids. Astronomy & Astrophysics, 2023; 672: A85 DOI: 10.1051/0004-6361/202244775
2. Princeton University. (2023, April 7). How to see the invisible: Using the dark matter distribution to test our cosmological model. ScienceDaily. Retrieved April 14, 2023 from www.sciencedaily.com/releases/2023/04/230407215847.htm

Episode 530 - Fully recyclable electronics

Electronics power the modern world, but they come at a high environmental and energy cost. E-waste a serious problem as many of the elements in modern electronics cannot be easily recycled. Is there a way to produce electronics that are more environmentally friendly? Is it possible to make a circuit board or more simply even a transistor that doesn't rely on silicon? Can you imagine a Silicon Valley without actual silicon? Its possible to make recyclable electronics without silicon and instead relying only on carbon and cellulose. How can you get away from the use of chemicals or high heat in circuit fabrication?

1. Nicholas X. Williams, George Bullard, Nathaniel Brooke, Michael J. Therien, Aaron D. Franklin. Printable and recyclable carbon electronics using crystalline nanocellulose dielectrics. Nature Electronics, 2021; DOI: 10.1038/s41928-021-00574-0
2. Shiheng Lu, Brittany N. Smith, Hope Meikle, Michael J. Therien, Aaron D. Franklin. All-Carbon Thin-Film Transistors Using Water-Only Printing. Nano Letters, 2023; 23 (6): 2100 DOI: 10.1021/acs.nanolett.2c04196

Episode 529 - Listening in on conversations inside your body

Your body is constantly communicating about what's happening outside and inside of it, but how can we listen in. When your immune system is responding to a virus, or a wound is healing, there are lots of signals to decode if only we could hear them. By amplifying the signals inside your body with special folding DNA and transistors we can understand how our body responds. The brain's neural networks are a treasure trove of information if we're able to blend in and listen. Using a microbot you can get precise information from on inside in the brain rather than relying on external information.

1. Xudong Ji, Xuanyi Lin, Jonathan Rivnay. Organic electrochemical transistors as on-site signal amplifiers for electrochemical aptamer-based sensing. Nature Communications, 2023; 14 (1) DOI: 10.1038/s41467-023-37402-2
2. Eunhee Kim, Sungwoong Jeon, Yoon‐Sil Yang, Chaewon Jin, Jin‐young Kim, Yong‐Seok Oh, Jong‐Cheol Rah, Hongsoo Choi. A Neurospheroid‐Based Microrobot for Targeted Neural Connections in a Hippocampal Slice. Advanced Materials, 2023; 35 (13) DOI: 10.1002/adma.202208747

Episode 528 - How our senses pass information to our brains

How does your body pass information along to your brain? The thalamus connects those sensory inputs back to your cerebral cortex but it's a lot sparser than you'd think. The synapses that link your senses to your cortex are often weak and rare, but their diversity gives them a boost. Lots of diverse synapses with different strengths help you perceive the world more clearly. Do both your eyes get equally treated by your brain?

1. Aygul Balcioglu, Rebecca Gillani, Michael Doron, Kendyll Burnell, Taeyun Ku, Alev Erisir, Kwanghun Chung, Idan Segev, Elly Nedivi. Mapping thalamic innervation to individual L2/3 pyramidal neurons and modeling their ‘readout’ of visual input. Nature Neuroscience, 2023; DOI: 10.1038/s41593-022-01253-9
2. Joel Bauer, Simon Weiler, Martin H.P. Fernholz, David Laubender, Volker Scheuss, Mark Hübener, Tobias Bonhoeffer, Tobias Rose. Limited functional convergence of eye-specific inputs in the retinogeniculate pathway of the mouse. Neuron, 2021; DOI: 10.1016/j.neuron.2021.05.036

Episode 527 - Concrete in space from blood, sweat, tears and chips

Building a habitat on Mars or the Moon is hard work, but it's a lot easier if you can make your own building materials. Animal blood has historically been used as a binding agent for mortar, so could human blood help on Mars? You can make your own building materials on the Moon or Mars that are far stronger than on earth especially if you add tears and blood. Maybe you don't want to use blood in when building your martian home, but would you sacrifice your potato chips? Potato chips and some extra salt will can make for super strong building materials on the Moon or Mars. Is there ways to enhance the performance of concrete by using other industries waste byproducts? All waste has to be re-used when you're in space, but here on earth using waste water and waste steel can help boost concrete.

1. Aled D. Roberts, Nigel S. Scrutton. StarCrete: A starch-based biocomposite for off-world construction. Open Engineering, 2023; 13 (1) DOI: 10.1515/eng-2022-0390
2. Aled D. Roberts, Dominic R. Whittall, Rainer Breitling, Eriko Takano, Jonny J. Blaker, Sam Hay, Nigel S. Scrutton. Blood, sweat and tears: extraterrestrial regolith biocomposites with in vivo binders. Materials Today Bio, 2021; 100136 DOI: 10.1016/j.mtbio.2021.100136
3. Rajeev Roychand, Biplob Kumar Pramanik, Guomin Zhang, Sujeeva Setunge. Recycling steel slag from municipal wastewater treatment plants into concrete applications – A step towards circular economy. Resources, Conservation and Recycling, 2020; 152: 104533 DOI: 10.1016/j.resconrec.2019.104533

Episode 526 - Capturing biological process in action

Seeing how something happens makes it much easier to understand. Biological process can be very hard to capture with images or video. Understanding how a protein requires thinking in 3D but to take images of them we often have to 'snap freeze' them in place. How can lasers, ions and quantum mechanics be used to help capture a protein in motion. PCR based diagnostics tests are accurate but require a lot of setup and expertise. Can you make a PCR test more like a point of care test using bio-luminescence.

1. Shiny Maity, Brad D. Price, C. Blake Wilson, Arnab Mukherjee, Matthieu Starck, David Parker, Maxwell Z. Wilson, Janet E. Lovett, Songi Han, Mark S. Sherwin. Triggered Functional Dynamics of AsLOV2 by Time‐Resolved Electron Paramagnetic Resonance at High Magnetic Fields. Angewandte Chemie International Edition, 2023; 62 (13) DOI: 10.1002/anie.202212832
2. Harmen J. van der Veer, Eva A. van Aalen, Claire M. S. Michielsen, Eva T. L. Hanckmann, Jeroen Deckers, Marcel M. G. J. van Borren, Jacky Flipse, Anne J. M. Loonen, Joost P. H. Schoeber, Maarten Merkx. Glow-in-the-Dark Infectious Disease Diagnostics Using CRISPR-Cas9-Based Split Luciferase Complementation. ACS Central Science, 2023; DOI: 10.1021/acscentsci.2c01467

Episode 525 - Life in a radiation exclusion zone and #2023MMM

Life in a radiation exclusion zone is challenging but not impossible. We find out about tales of survival, endurance and adaption in radiation zones and in March Mammal Madness. How does life adapt to high exposure of toxic chemicals, radiation and heavy metals? Studying the DNA of differing animal populations in Chernobyl helps researchers understand how life responds to environmental disasters.  What's more stressful for wild boar - humans or a radiation disaster zone? Around Fukashima wild boar and snakes are thriving in what is classified as a radiation disaster zone. We also preview March Mammal Madness and find out about the different divisions in this year's edition.

1. March Mammal Madness resources compiled by Arizona State University https://libguides.asu.edu/marchmammalmadness
2. Megan N. Dillon, Rachael Thomas, Timothy A. Mousseau, Jennifer A. Betz, Norman J. Kleiman, Martha O. Burford Reiskind, Matthew Breen. Population dynamics and genome-wide selection scan for dogs in Chernobyl. Canine Medicine and Genetics, 2023; 10 (1) DOI: 10.1186/s40575-023-00124-1
3. Kelly Cunningham, Thomas G. Hinton, Jared J. Luxton, Aryn Bordman, Kei Okuda, Lynn E. Taylor, Josh Hayes, Hannah C. Gerke, Sarah M. Chinn, Donovan Anderson, Mark L. Laudenslager, Tsugiko Takase, Yui Nemoto, Hiroko Ishiniwa, James C. Beasley, Susan M. Bailey. Evaluation of DNA damage and stress in wildlife chronically exposed to low-dose, low-dose rate radiation from the Fukushima Dai-ichi Nuclear Power Plant accident. Environment International, 2021; 155: 106675 DOI: 10.1016/j.envint.2021.106675

 

Episode 524 - Bacteria’s sneaky 1-2 punch to get into your brain

Bacteria uses a clever 1-2 punch to make it through our central nervous systems defenses. The way bacteria can get through the outer layers of the meninges relies on knowing exactly what how the brain will respond to infection. Painful headaches are a key part of meningitis, but that pain response is actually opening the door for a sneak attack. Understanding how bacterial infections get into the brain will help develop new treatment pathways for meningitis. When bacteria come under attack themselves, they use signalling pathways that we can learn from. By studying the way bacteria defend themselves we could find common tools to use to precisely regulate human cells.

1. Felipe A. Pinho-Ribeiro, Liwen Deng, Dylan V. Neel, Ozge Erdogan, Himanish Basu, Daping Yang, Samantha Choi, Alec J. Walker, Simone Carneiro-Nascimento, Kathleen He, Glendon Wu, Beth Stevens, Kelly S. Doran, Dan Levy, Isaac M. Chiu. Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion. Nature, 2023; DOI: 10.1038/s41586-023-05753-x
2. Hannah E. Ledvina, Qiaozhen Ye, Yajie Gu, Ashley E. Sullivan, Yun Quan, Rebecca K. Lau, Huilin Zhou, Kevin D. Corbett, Aaron T. Whiteley. An E1–E2 fusion protein primes antiviral immune signalling in bacteria. Nature, 2023; DOI: 10.1038/s41586-022-05647-4

Episode 523 - Sinking carbon out of seawater and carbon storage in wood

Our oceans and waterways are our largest carbon sinks and they're overflowing with CO2. Too much CO2 in our waterways can cause tremendous local damage, but there may be ways to clean that up. Using a cyclic process without messy membranes you can get water to release the CO2 captured inside. Extracting excess CO2 from oceans could be possible with only some clever chemistry cells with no waste byproducts. Now that you've got CO2 out of the ocean, what are you going to do with it? Make it work for you. Carbon sequestration can be more useful than just pumping it into the ground. With the right techniques you can use excess CO2 to improve construction materials. 

1. Seoni Kim, Michael Nitzsche, Simon B Rufer, Jack R. Lake, Kripa Kiran Varanasi, T. Alan Hatton. Asymmetric chloride-mediated electrochemical process for CO2 removal from oceanwater. Energy & Environmental Science, 2023; DOI: 10.1039/D2EE03804H
2. Soumyabrata Roy, Firuz Alam Philip, Eliezer Fernando Oliveira, Gurwinder Singh, Stalin Joseph, Ram Manohar Yadav, Aparna Adumbumkulath, Sakib Hassan, Ali Khater, Xiaowei Wu, Praveen Bollini, Ajayan Vinu, George Shimizu, Pulickel M. Ajayan, Md Golam Kibria, Muhammad M. Rahman. Functional wood for carbon dioxide capture. Cell Reports Physical Science, 2023; 4 (2): 101269 DOI: 10.1016/j.xcrp.2023.101269

Episode 522 - Making hydrogen greenly from Seawater

​Hydrogen comes in all kinds of colours but what does that mean? Hydrogen has a role to play in a decarbonised world as long as we can produce it greenly. It's no good producing green hydrogen if you use up another valuable resource or create another kind of waste. Water water everywhere, but not a drop to electrolyse. Using seawater to make hydrogen has challenges. How can we use the abundant seawater resource to make green energy sources without producing nasty by products? 

1. Suraj Loomba, Muhammad Waqas Khan, Muhammad Haris, Seyed Mahdi Mousavi, Ali Zavabeti, Kai Xu, Anton Tadich, Lars Thomsen, Christopher F. McConville, Yongxiang Li, Sumeet Walia, Nasir Mahmood. Nitrogen‐Doped Porous Nickel Molybdenum Phosphide Sheets for Efficient Seawater Splitting. Small, 2023; 2207310 DOI: 10.1002/smll.202207310

Episode 521 - Galaxies at the Cosmic Dawn

Using the JWST to peer into the Cosmic dawn of the universe. The JWST enables researchers to peer into the earliest galaxies in our universe. 250 Million years is not a long time when it comes to a star or galaxy. With JWST researchers can see galaxies formed 250 million years after the Big Bang. To peer into the earliest universe you must use infrared to capture the faintest light. Using new instruments on the JWST researchers are able to see galaxies from 13.25 billion years ago. JWST also lets researchers investigate strange new types of spiral galaxies from the Cosmic Noon.

1. Yoshinobu Fudamoto, Akio K. Inoue, Yuma Sugahara. Red Spiral Galaxies at Cosmic Noon Unveiled in the First JWST Image. The Astrophysical Journal Letters, 2022; 938 (2): L24 DOI: 10.3847/2041-8213/ac982b
2. University of California - Santa Cruz. (2022, December 9). Astronomers report most distant known galaxies, detected and confirmed. ScienceDaily. Retrieved January 2, 2023 from www.sciencedaily.com/releases/2022/12/221209135542.htm

Episode 520 - There and back again - tales from a wandering space probe

Hayabusa2 had an exciting voyage across our solar system, getting into dust ups and even coming back home again with data to share. We've been tracking the long journey of Hayabusa2 over the 10 years of this podcast, and we're now getting interesting data from the returned samples. The Hayabusa2 probe shot at the asteroid Ryugu and brought back proof for JAXA to study and it tells tales of a very early time in our solar system. Ryugu is much much older than we thought, born only 1.8 million years after the formation of our solar system. How does a planetary system form and why are some planets in a flat line and others really odd. Our Nepture is an anomaly not just in our solar system but also compared to others. What happened to all the other 'Hot Neptune' exoplanets? Did they get burnt off or flung away?

1. Kaitlyn A. McCain, Nozomi Matsuda, Ming-Chang Liu, Kevin D. McKeegan, Akira Yamaguchi, Makoto Kimura, Naotaka Tomioka, Motoo Ito, Naoya Imae, Masayuki Uesugi, Naoki Shirai, Takuji Ohigashi, Richard C. Greenwood, Kentaro Uesugi, Aiko Nakato, Kasumi Yogata, Hayato Yuzawa, Yu Kodama, Kaori Hirahara, Ikuya Sakurai, Ikuo Okada, Yuzuru Karouji, Satoru Nakazawa, Tatsuaki Okada, Takanao Saiki, Satoshi Tanaka, Fuyuto Terui, Makoto Yoshikawa, Akiko Miyazaki, Masahiro Nishimura, Toru Yada, Masanao Abe, Tomohiro Usui, Sei-ichiro Watanabe, Yuichi Tsuda. Early fluid activity on Ryugu inferred by isotopic analyses of carbonates and magnetite. Nature Astronomy, 2023; DOI: 10.1038/s41550-022-01863-0.
2. V. Bourrier, O. Attia, M. Mallonn, A. Marret, M. Lendl, P.-C. Konig, A. Krenn, M. Cretignier, R. Allart, G. Henry, E. Bryant, A. Leleu, L. Nielsen, G. Hebrard, N. Hara, D. Ehrenreich, J. Seidel, L. dos Santos, C. Lovis, D. Bayliss, H. M. Cegla, X. Dumusque, I. Boisse, A. Boucher, F. Bouchy, F. Pepe, B. Lavie, J. Rey Cerda, D. Ségransan, S. Udry, T. Vrignaud. DREAM. Astronomy & Astrophysics, 2023; 669: A63 DOI: 10.1051/0004-6361/202245004

Episode 519 - Evolving beaks and wild chickens

How did birds end up with their trademark beaks? You can broadly group birds into two categories, ancient and modern jaws or beaks. We thought mobile beaks were a modern invention but new fossils overturn this idea. Just when did birds first develop their modern mobile beaks? Wild jungle fowl were domesticated to become the chickens we love today. But wild chickens are not isolated completely from modern ones. Gene transfers between wild and domesticated chickens are eroding the genetic diversity of the species.

1. Benjamin A. Tonelli, Casey Youngflesh, Morgan W. Tingley. Geomagnetic disturbance associated with increased vagrancy in migratory landbirds. Scientific Reports, 2023; 13 (1) DOI: 10.1038/s41598-022-26586-0
2. Meng Yue Wu, Giovanni Forcina, Gabriel Weijie Low, Keren R. Sadanandan, Chyi Yin Gwee, Hein van Grouw, Shaoyuan Wu, Scott V. Edwards, Maude W. Baldwin, Frank E. Rheindt. Historic samples reveal loss of wild genotype through domestic chicken introgression during the Anthropocene. PLOS Genetics, 2023; 19 (1): e1010551 DOI: 10.1371/journal.pgen.1010551

Episode 518 - Aurora on Jupiter and on Earth

Aurora are stellar examples of high energy physics. You need to be at the right spot to find Aurora on earth, but its not quite the same on Jupiter. What governs where and how an aurora will form? Earth and Jupiter are very different in size and speed, but why are our Auroras so different? How does Jupiter's magnetosphere bring all it's moons into line? What happens when an small independent moon brushes up against a super sized neighbour? Ganymede has it's own indepedent magnetic field. So what would happen if it got gobbled up by Jupiter?

1. Binzheng Zhang, Peter A. Delamere, Zhonghua Yao, Bertrand Bonfond, D. Lin, Kareem A. Sorathia, Oliver J. Brambles, William Lotko, Jeff S. Garretson, Viacheslav G. Merkin, Denis Grodent, William R. Dunn, John G. Lyon. How Jupiter’s unusual magnetospheric topology structures its aurora. Science Advances, 2021; 7 (15): eabd1204 DOI: 10.1126/sciadv.abd1204
2. R. W. Ebert, S. A. Fuselier, F. Allegrini, F. Bagenal, S. J. Bolton, G. Clark, J. E. P. Connerney, G. A. DiBraccio, W. S. Kurth, S. Levin, D. J. McComas, J. Montgomery, N. Romanelli, A. H. Sulaiman, J. R. Szalay, P. Valek, R. J. Wilson. Evidence for Magnetic Reconnection at Ganymede's Upstream Magnetopause During the PJ34 Juno Flyby. Geophysical Research Letters, 2022; 49 (23) DOI: 10.1029/2022GL099775

Episode 517 - Cute green balls of algae and a changing climate

In the northern reaches of Japan in a idyllic lake, cute green balls of algae are battling for survival. It sounds like an anime, but cute green algae balls, Marimo, are battling stellar forces. Too much sunlight can endanger the cute green algae balls, the Marimo. Having too much sunlight can be just as bad for algae as too little. How can brown algae help fight back against climate change? Algae have changed the climate once before, so can they do it again? If you were to quantify the carbon sequestration of algae, would it really make an impact globally?

1. Akina Obara, Mari Ogawa, Yoichi Oyama, Yoshihiro Suzuki, Masaru Kono. Effects of High Irradiance and Low Water Temperature on Photoinhibition and Repair of Photosystems in Marimo (Aegagropila linnaei) in Lake Akan, Japan. International Journal of Molecular Sciences, 2022; 24 (1): 60 DOI: 10.3390/ijms24010060
2. Hagen Buck-Wiese, Mona A. Andskog, Nguyen P. Nguyen, Margot Bligh, Eero Asmala, Silvia Vidal-Melgosa, Manuel Liebeke, Camilla Gustafsson, Jan-Hendrik Hehemann. Fucoid brown algae inject fucoidan carbon into the ocean. Proceedings of the National Academy of Sciences, 2022; 120 (1) DOI: 10.1073/pnas.2210561119

Episode 517 - How our body senses and interacts with the world

Understanding how our body senses and interacts with the world. Scientists are only now beginning to understand how our body senses the world, hence the '21 Nobel Prizes. This Nobel prize wining research helped others find a connection between the gut and our sense of touch. Internal organ pain can be crippling and require side effect laden treatments. How do organs like the gut detect and transmit pain signals? The same mechanism to detect soft touch is used by your organs to send pain signals. How does our body precisely control temperature? What region of the brain measures and control what temperature to set itself to?

1. Zili Xie, Jing Feng, Timothy J. Hibberd, Bao Nan Chen, Yonghui Zhao, Kaikai Zang, Xueming Hu, Xingliang Yang, Lvyi Chen, Simon J. Brookes, Nick J. Spencer, Hongzhen Hu. Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity. Neuron, 2022; DOI: 10.1016/j.neuron.2022.11.015
2. Yoshiko Nakamura, Takaki Yahiro, Akihiro Fukushima, Naoya Kataoka, Hiroyuki Hioki, Kazuhiro Nakamura. Prostaglandin EP3 receptor–expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling. Science Advances, 2022; 8 (51) DOI: 10.1126/sciadv.add5463